Epitalon — 50mg

Epitalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide analog of Epithalamin, a polypeptide extract from bovine pineal gland. It was developed by the St. Petersburg Institute of Bioregulation and Gerontology under Vladimir Khavinson, whose team conducted the foundational research documenting both its molecular mechanisms and its effects in human aging populations. While many longevity compounds remain confined to in vitro or rodent models, Epitalon has been studied in elderly human subjects with measurable outcomes — an unusual distinction in this category.

The peptide's primary mechanism involves upregulation of TERT (telomerase reverse transcriptase), the catalytic subunit of telomerase, in human somatic cells that normally exhibit low or absent telomerase activity. Telomere shortening is a fundamental driver of cellular senescence and is strongly correlated with biological aging, making telomerase activation one of the most direct approaches to addressing this process. Studies in human subjects aged 60–80 demonstrated statistically significant telomere lengthening after Epitalon treatment — a finding that has generated continued scientific interest despite the small study sizes involved.

Beyond telomere biology, Epitalon modulates pineal gland function and melatonin secretion, influences circadian rhythm regulation, and has shown reductions in chromosomal aberrations in aging mouse populations. Separate lines of investigation have examined its effects on cancer incidence in long-term animal studies, where consistent reductions in spontaneous tumor formation have been reported. Its safety profile across multiple decades of research use in Russia is extensive, though large-scale Western RCTs remain an unmet need.